Autoinflammatory syndromes in children: Genetics, disease mechanisms, diagnostic markers, and therapeutic targets (AID-NET)

Fragestellung

We hypothesize that dysregulation of innate immune mechanisms, e.g. alternative secretory pathways, phagocyte activation, reduced anti-inflammatory activities, or dysfunction of PRRs, plays a key role in Autoinflammatory Diseases (AID).

Konzept

Clinical Registry, Biobanks (DNA/RNA/Serum), and translational projects: In the collaborative clinical research part we will include all patients with AID into a clinical registry and patient material into a DNA/RNA and a serum bank. The patient material will be used for the identification of genetic or serologic markers of the disease. Future use will allow translating the newly discovered pathogenic mechanisms of the innate immune system into feasible tools improving patient care via assessing the potential of novel biomarkers or genetic tests in monitoring disease activity of patients

Patienten

Autoinflammatorische Syndrome (CINCA, MWS, FMF, TRAPS, SOJIA)

Studienleitung

Prof. Dirk Föll, Prof. J. Roth

Universitäts-Kinderklinik
Albert-Schweitzer-Str. 33
D-48149 Münster

Co-Investigators: Neudorf/Lainka (University of Essen)
Haas (University of Greifswald)
Lohse (LMU Munich)
Schmitz/Schulze-Osthoff (University of Duesseldorf)
Greten (University Hospital Munich)
Nickel (University of Heidelberg)
Gerke (University of Muenster)

Mögliche Beteiligung durch GKJR-Mitglieder

Einschluss von Patienten;
Bereitsstellung von Patientendaten;
Zusendung von Serum zur Bestimmung von Entzündungsmarkern;
Zusendung von EDTA-Blut/DNA 

Laboradresse:
Universität Münster
Institut für Immunologie
Prof. Föll
Röntgenstr. 21
D-48149 Münster