AID-NET: Autoinflammatory syndromes in children: Genetics, disease mechanisms, diagnostic markers, and therapeutic targets


We hypothesize that dysregulation of innate immune mechanisms, e.g. alternative secretory pathways, phagocyte activation, reduced anti-inflammatory activities, or dysfunction of PRRs, plays a key role in Autoinflammatory Diseases (AID).


Clinical Registry, Biobanks (DNA/RNA/Serum), and translational projects: In the collaborative clinical research part we will include all patients with AID into a clinical registry and patient material into a DNA/RNA and a serum bank. The patient material will be used for the identification of genetic or serologic markers of the disease. Future use will allow translating the newly discovered pathogenic mechanisms of the innate immune system into feasible tools improving patient care via assessing the potential of novel biomarkers or genetic tests in monitoring disease activity of patients

Please, find more information on the site of the AID-Register.


Autoinflammatory syndroms (CINCA, MWS, FMF, TRAPS, SOJIA)
as well as PFAPA and clinically defined AID diseases

Aktueller Stand

PD Dr. Elke Lainka berichtete über den Stand des Projektes im Februar 2014.


Dr. med. Ulrich Neudorf
Telefonsprechstunde Do 13:30-14:00
Telefon: 0201 723-3376

Dr. med. Elke Lainka
Telefonsprechstunde Do 13:30-14:00
Telefon: 0201 723-3632
Fax: 0201 723-5394

Prof. Dr. med. Tim Niehues
HELIOS-Klinikum Krefeld
Lutherplatz 40
47805 Krefeld

Mögliche Beteiligung durch GKJR-Mitglieder

Einschluss von Patienten (sowohl Kinder als auch betroffene Erwachsene);
Bereitsstellung von Patientendaten;
Zusendung von Serum zur Bestimmung von Entzündungsmarkern;
Zusendung von EDTA-Blut/DNA 

Universitätsklinikum Münster
Klinik für Pädiatrische Rheumatologie und Immunologie
Albert-Schweitzer-Campus 1
Gebäude D3
Domagkstraße 3
D-48149 Münster